Dynamics, Nanoscopy & Chemometrics (DyNaChem)



  • Congratulations to Lucas M. Uriarte for his oral Ph.D. defense (Jan. 2021).
  • Congratulations to Ali Eftekhari for his oral presentation prize at the French Swiss Photochemistry Symposium (Jan. 2021).
  • New publication in Analytical Science: A chemometric view of hyperspectral images, 2020, DOI
  • New publication in Int. J. Mol. Sci.: Control of the Photo-isomerization Mechanism in 3H-Naphthopyrans to Prevent Formation of Unwanted Long Lived Photoproduct,2020, DOI
  • Congratulations to Lucas M. Uriarte for his flash presentation prize at the 5th Nanosynergetics Workshop (Nov. 2020).
  • Congratulations to Raffaele Vitale, he is the recipient of the 2020 Young Statistician Award, which is aimed to recognize the work of young people in introducing innovative methods, promoting the use of statistics and/or successfully using it in the daily practice (Oct. 2020).
  • Congratulations to Cyril Ruckebusch, he has been nominated Associate Editor-in-Chief for Journal of Chemometrics (Wiley).
  • Welcome to a new PhD student, Xingjie Fu.  Nano-Synergy between fluorescent proteins and metallic nanoparticles to design new nano-probes for super-resolution imaging. Coll. G. Laurent (PPSM), M. Weik (CEA Grenoble), J. Abe (Aoyama Gakuin Univ.), H. Miyasaka (Oct. 2020).
  • Welcome to Dr. Raffaele Vitale as new Assistant Professor at Polytech'Lille (ATER), (Sept. 2020)
  • Congratulation to Aude Bouchet, she is responsible for the LASIRE of the selected ANR PRC MESOMORPHICS (Mesomorph POM-based hybrids materials for photonics, PI Guillaume Izzet) (Sept. 2020)
  • Congratulations to Olivier Devos, he was elected as Director of IC2M department at Polytech'Lille .


Scientists (2019-2020):
Aude BOUCHET (Assistant Professor IUT, MCF) 0000-0002-4765-8876
Olivier DEVOS (Assistant Professor Polytech'Lille, MCF) olivier-devos 0000-0002-3354-0420
Cyril RUCKEBUSCH (Professor Polytech'Lille) 0000-0001-8120-4133
Michel SLIWA (Director CNRS-Team Leader) 0000-0002-5073-8180
Raffaele VITALE (Assistant Professor Polytech'Lille, ATER)0000-0002-7497-1673
Lucas MARTINEZ URIARTE (Post Doctorate, ANR DynOCP)0000-0001-6693-4699

Doctoral students (2019-2021):

Xingjie Fu (co-direction, ENS Paris Saclay, CNRS IRP Nano-synergetics)
Mohamad AHMAD (co-tutelle, U. Modena)
Dario CEVOLI (co-tutelle, KULeuven)
Ali EFTEKHARI (Region / Univ. Lille / IRP Nano-synergetics)
Stanislaw NIZINSKI (co-direction, Pr. G. Burdzinski Adam Mickiewicz University)

Master Students (2021):

Clara Wattiez (6 Months, U. Lille)
Cedric Mittelheisser Master 2 / Pre-doctoral (11 Months, ENS Paris-Saclay)

Visitors, Invited (2019-2021):

Laureen Coic (3 months, Liège University), Hassan Alsabea Doctoral student (1 week, U. Rennes), Gotard Burdzinski Professor (2 sem., Adam Mickiewicz University) Asmund RINNAN Professor (2 sem., Copenhagen University) Patricia FIRMANI Doctoral student (3 months, U. Rome) Tatsuhiro NAGASAKA Doctoral student (1 month, Osaka Univ.) Keisuke NAGAMINE Master (3 months, U. Yamagata), Nicolas MILLECAMPS DUT (2 months, Univ. Lille)

Research & SKILL

Members of the team "Dynamics, Nanoscopy and Chemometrics" are interested in micro- and nano-imaging of photoactive bio-systems, particularly the study of the photochemistry & photodynamics of molecules, proteins and emissive organic and hybrid nanoparticles for super-resolution fluorescence biological imaging. Our speciality is hyperspectral & super-resolved nanometer-scale imaging of ultrafast processes, and the development of new instrumentation and methodologies for the analysis of these hyperspectral super-resolved data. Our goal is to build detailed photochemical and photophysical models of new and commercial photo-active systems to optimize their use and the development of new bio-materials.

KEY Words

  • Photochemistry, Photochromism, Time-resolved spectroscopy, Fluorescence, Imaging, Single molecule, Polarisation
  • Chemometrics, Data analysis, Image analysis, Hyperspectral, Spectral unmixing, Super-resolution, Deconvolution
  • Organic  & hybrid luminescent Nanoparticles, Photo-active proteins

Techniques & Methods

  • Single photon timing, Femtosecond transient absorption, Nanosecond flash photolysis

TEAM's News

01 Mar. 2021 Welcome to Lucas M. Uriarte (Post Doctorate, 1 year)
01 Mar. 2021 Welcome to Clara Wattiez (M2, 6 months)
01 Feb. 2021 Welcome to Giulia Spinaci (M2, 6 months)
01 Nov. 2020 Welcome to Cedric Mittelheisser for a pre doctoral training (6 months)
20 Oct. 2020 Team meeting
01 Oct. 2020 Welcome to Laureen Coic (3 months, Ph.D. from Liège University)
01 Oct. 2020 Welcome to Xingjie Fu, new Ph.D. student
24 Jul. 2020 Lunch group meeting at Olivier apartment
07 Jul. 2020 Restarting team meeting at the laboratory.
22 Apr. 2020. Second team meeting during Covid-19
17 Mar. 2020. First team meeting during Covid-19
22 Feb. 2020. Welcome (1 week) of Hassan Alsabea for time-resolved experiments, Doctoral student of U. Rennes
18 Feb. 2020. Aude & Ali attended the Picoquant 12th International Course on time resolved microscopy
11 Feb. 2020. Visit / Seminar of Dr. M. Surrin, U. Mons
1 Feb. 2020. Welcome Cedric Mittelheisser (6 month), Master 2 student of ENS Paris-Saclay
20 Jan. 2020. Visit / experiments (1 weeks) of Lucas to Japan in Abe sensei laboratory
6 Jan. 2020. Congratulation to Dario for his oral presentation at QBI 2020
1 Jan. 2020. Starting of the LAI Lille-KULeuven, High Performance Fluorescence Nano-imaging

28 Nov. 2019 Congratulation to Siewert Hugelier for the prize of the best Ph.D. thesis 2019 « Recherche Internationale en Sciences et Technologies »
15 Nov. 2019. Visit / Seminar of Dr. Siewert Hugelier, KU Leuven
1 Nov. 2019. Welcome (3 years) of Ali Eftekahri, new doctorale student (Region / Lille / LIA)
4 Oct. 2019. Congratulation to Lucas lauréat for the best poster prize (ACS Omega) at Let there be…LIGHT! Conference
15 Sept. 2019. Welcome (2 weeks) of Prof. Gotard Burdzinski, Inivted Professor U. Adam Mickiewicz
1 Sept. 2019. Welcome (1 year) de Dario Cevoli, Doctorale student co-tutelle KULeuven
1 Sept. 2019. Welcome Stanislaw Nizinski (6 month), Doctorale student of U. Adam Mickiewicz
27 Aout 2019. Congratulation to Stanislaw & Lucas for their oral presentation at Light&Life 2019 Conference
17 Jul. 2019. Visit / Seminar of Dr. T. Ha-Duhong, U. Paris Diderot
3 Jun. 2019. Accueil de Ali Efthekahri, Chercheur invité
4 Avr. 2019. Visit / Seminar of Dr. M. Cammarata, U. Rennes
1 Avr. 2019. Welcome (1 month) of Tatsuhiro Nagasaka, Doctorale student of U. Osaka
1 Avr. 2019. Welcome (4 months) of Nicolas Millecamps, 2nd Year DUT U. Lille
1 Mar. 2019. Welcome (6 months) of Mahdiyeh Ghaffari, Post Doctorate
28 Feb. 2019. Visit / Seminar of Pr. S. Meech, U. East Anglia
10 Feb. 2019. Visit / Seminar of Pr. T. Asahi, U. Ehime
10 Jan. 2019. Welcome (7 months) of Patricia Firmani, Doctorale student of U. Rome
1 Jan. 2019. Starting of l'ANR DynOCP

Recent Publications

  • Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy, Nature Communication, 2020, DOI
  • Essential Spectral Pixels for Multivariate Curve Resolution of Chemical Images, Analytical Chemistry, 2019, DOI
  • Photochemical multivariate curve resolution models for the investigation of photochromic systems under continuous irradiation, Analytica Chimica Acta, 2019, DOI
  • Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography, Nature Chemistry, 2018, DOI
  • Fusion of Ultraviolet–Visible and Infrared Transient Absorption Spectroscopy Data to Model Ultrafast Photoisomerization, Journal of Physical Chemistry Letters, 2017, DOI
  • Sparse deconvolution of high-density super-resolution images, Scientific Reports, 2016, DOI


  • LAI Lille-KULeuven, International Laboratory on High Performance Fluorescence Nano-imaging
  • ANR PRC MESOMORPHICS, Mesomorph POM-based hybrids materials for photonics, ANR-20-CE06-0021
  • ANR PRC DynOCP, Time resolved insights into the photo-activation mechanism of OCP by combined ultrafast optical spectroscopy and serial femtosecond crystallography, ANR-18-CE11-0005
  • IRP Nano-synergetics French-Japan, Photo-active Nanomaterials with Cooperative and Synergetic Responses
  • ANR PRCE Blink, Multi-luminescent up-converting nanohybrids with controlled blinking for super-resolution imaging and single particle tracking, ANR-15-CE09-0020
  • ANR PRC BioXfel, Elucidating structural intermediates of fluorescent proteins using X-ray free electron lasers and ultra-fast UV-visible and infrared spectroscopies, ANR-15-CE32-0004
  • ANR JCJC Ultrafast Nanoscopy, Understanding energy and charge carrier dynamics in fluorescent organic nanoparticles: ultrafast and high resolution microscopy, ANR-14-CE08-0015