Vous êtes invités au prochain séminaire organisé par le laboratoire :

Supramolecular assemblies of DNA and p-conjugated molecules

par  Mathieu Surin maître de recherches du F.R.S.-FNRS et chargé de cours à temps partiel à l’université de Mons

DNA is a chiral biomolecule with a formidable information density, and as such it has been utilized as a template to achieve for example, sequence-controlled polymers, helical supramolecular structures, and complex 3D chiral shapes with sub-nm resolution.[1-3] In this context, our seminar will report our latest results on a series of cationic p-conjugated molecules and polymers, which show unique chiroptical signatures upon DNA binding. We show that these signatures are strongly DNA sequence-dependent, and we explore the effects of chiral induction, self-assembly, and cooperativity.[4,5] Two examples are discussed: i) the templating of an azobenzene-based photoactive molecule, which can reversibly switches from trans to cis configurations in interaction with DNA, is utilized to modulate the assembly of a multichromophoric stack along the DNA template; ii) the helical wrapping of a polythiophene around DNA, which allows us to monitor an enzymatic activity (the cleavage of DNA by an endonuclease) through chiroptical signals in real time.[6,7]

References

[1] J. Niu, R. Hili, D. R. Liu, Nat. Chem. 2013, 5, 282.

[2] M. Surin, Polym. Chem. 2016, 7, 4137.

[3] N.C. Seeman, H.F. Sleiman, Nat. Rev. Mater. 2017, 3, 17068.

[4] J. Rubio-Magnieto, M. Kumar, P. Brocorens, J. Idé, S.J. George, R. Lazzaroni, M. Surin, Chem. Commun. 2016, 52, 13873.

[5] N. Holmgaard List, J. Knoops, J. Rubio-Magnieto, J. Idé, D. Beljonne, P. Norman, M. Surin, M. Linares, J. Am. Chem. Soc. 2017, 139, 14947.

[6] J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J. 2018, 24, 706.

[7] M. Fossépré, M. Trévisan, V. Cyriaque, R. Wattiez, D. Beljonne, S. Richeter, S. Clément, M. Surin, ACS Applied Bio Materials, 2019, 2, 2125.